No borna disease virus-specific RNA detected in blood of race horses and jockeys

被引：8

作者：

Kim, Yong-Ku

Noh, Kyung-Bo

Han, Chang-Su

Moon, Ju-Young

Yoon, Do-Kyung

Song, Ki-Joon

Kim, Dai-Jin

Kubera, Marta

Maes, Michael

Song, Jin-Won

机构：

[1] Korea Univ, Coll Med, Dept Psychiat, Seoul 136701, South Korea

[2] Korea Univ, Coll Med, Dept Microbiol, Seoul 136701, South Korea

[3] Korea Univ, Coll Med, Inst Viral Dis, Seoul 136701, South Korea

[4] Korea Univ, Coll Med, Dept Family Med, Seoul 136701, South Korea

[5] Catholic Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[6] Polish Acad Sci, Inst Pharmacol, Dept Endocrinol, PL-00901 Warsaw, Poland

[7] MCare4U Outpatient Clin, Lier, Belgium

来源：

ACTA NEUROPSYCHIATRICA | 2006年 / 18卷 / 3-4期

关键词：

BDV; horse; jockey; PCR; psychiatric disorder;

D O I：

10.1111/j.1601-5215.2006.00118.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.

引用

页码：177 / 180

页数：4

共 23 条

[1] Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran [J].