Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates

被引：134

作者：

Jiang, Kun ^{[1
]}

Peng, Jing ^{[1
]}

Cui, Hai-Lei ^{[1
]}

Chen, Ying-Chun ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Dept Med Chem, Educ Minist,W China Sch Pharm, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 26期

基金：

中国国家自然科学基金;

关键词：

GROWTH-HORMONE SECRETAGOGUES; ENANTIOSELECTIVE FLUORINATION; TERTIARY STEREOCENTERS; ADJACENT QUATERNARY; CONJUGATE ADDITION; GAMMA-BUTENOLIDES; MANNICH REACTION; CONSTRUCTION; ACETATES; SUBSTITUTION;

D O I：

10.1039/b905177e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The organic Lewis base-catalysed asymmetric allylic alkylation of 3-substituted oxindoles with Morita-Baylis-Hillman carbonates is reported, affording multifunctional oxindoles with adjacent quaternary and tertiary chiral centres (dr up to 92 : 8, 86-97% ee).

引用

收藏

页码：3955 / 3957

页数：3

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