Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis

被引：11

作者：

Leonard, WR ^{[1
]}

Belyk, KM ^{[1
]}

Bender, DR ^{[1
]}

Conlon, DA ^{[1
]}

Hughes, DL ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 24期

关键词：

D O I：

10.1021/ol0261940

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relative and absolute configuration of the pneumocandin B-0 side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.

引用

页码：4201 / 4204

页数：4