Genetic and cell biological analysis of integrin outside-in signaling

被引：581

作者：

Legate, Kyle R. ^{[1
]}

Wickstroem, Sara A. ^{[1
]}

Faessler, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 04期

关键词：

Integrin signaling; actin cytoskeleton; growth factor receptors; cell adhesion; FOCAL ADHESION KINASE; GROWTH-FACTOR-I; GTPASE-ACTIVATING PROTEIN; SMOOTH-MUSCLE-CELLS; BETA CYTOPLASMIC DOMAIN; PHOSPHOTYROSINE-BINDING DOMAIN; GLYCOPROTEIN-IIB-IIIA; DYSTROPHIC MDX MICE; RHO-FAMILY GTPASES; IGF-I;

D O I：

10.1101/gad.1758709

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their ligands induces a vast number of structural and signaling changes within the cell. Large, multimolecular complexes assemble onto the cytoplasmic tails of activated integrins to engage and organize the cytoskeleton, and activate signaling pathways that ultimately lead to changes in gene expression. Additionally, integrin-mediated signaling intersects with growth factor-mediated signaling through various levels of cross-talk. This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling.

引用

页码：397 / 418

页数：22

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