Genetic and cell biological analysis of integrin outside-in signaling

被引：581

作者：

Legate, Kyle R. ^{[1
]}

Wickstroem, Sara A. ^{[1
]}

Faessler, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 04期

关键词：

Integrin signaling; actin cytoskeleton; growth factor receptors; cell adhesion; FOCAL ADHESION KINASE; GROWTH-FACTOR-I; GTPASE-ACTIVATING PROTEIN; SMOOTH-MUSCLE-CELLS; BETA CYTOPLASMIC DOMAIN; PHOSPHOTYROSINE-BINDING DOMAIN; GLYCOPROTEIN-IIB-IIIA; DYSTROPHIC MDX MICE; RHO-FAMILY GTPASES; IGF-I;

D O I：

10.1101/gad.1758709

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their ligands induces a vast number of structural and signaling changes within the cell. Large, multimolecular complexes assemble onto the cytoplasmic tails of activated integrins to engage and organize the cytoskeleton, and activate signaling pathways that ultimately lead to changes in gene expression. Additionally, integrin-mediated signaling intersects with growth factor-mediated signaling through various levels of cross-talk. This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling.

引用

页码：397 / 418

页数：22

共 284 条

[51] The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis [J].

Danen, EHJ ;

Sonneveld, P ;

Brakebusch, C ;

Fässler, R ;

Sonnenberg, A .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :1071-1086

[52] Proximal, selective, and dynamic interactions between integrin αIIβ3 and protein tyrosine kinases in living cells [J].

de Virgilio, M ;

Kiosses, WB ;

Shattil, SJ .

JOURNAL OF CELL BIOLOGY, 2004, 165 (03) :305-311

[53] p130Cas: a versatile scaffold in signaling networks [J].

Defilippi, P ;

Di Stefano, P ;

Cabodi, S .

TRENDS IN CELL BIOLOGY, 2006, 16 (05) :257-263

[54] The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading [J].

Degani, S ;

Balzac, F ;

Brancaccio, M ;

Guazzone, S ;

Retta, SF ;

Silengo, L ;

Eva, A ;

Tarone, G .

JOURNAL OF CELL BIOLOGY, 2002, 156 (02) :377-387

[55] Integrins regulate Rac targeting by internalization of membrane domains [J].

del Pozo, MA ;

Alderson, NB ;

Kiosses, WB ;

Chiang, HH ;

Anderson, RGW ;

Schwartz, MA .

SCIENCE, 2004, 303 (5659) :839-842

[56] Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion [J].

DeMali, KA ;

Barlow, CA ;

Burridge, K .

JOURNAL OF CELL BIOLOGY, 2002, 159 (05) :881-891

[57] RECEPTOR PROTEIN-TYROSINE PHOSPHATASE-ALPHA ACTIVATES PP60(C-SRC) AND IS INVOLVED IN NEURONAL DIFFERENTIATION [J].

DENHERTOG, J ;

PALS, CEGM ;

PEPPELENBOSCH, MP ;

TERTOOLEN, LGJ ;

DELAAT, SW ;

KRUIJER, W .

EMBO JOURNAL, 1993, 12 (10) :3789-3798

[58] Characterization of four mammalian numb protein isoforms - Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain [J].

Dho, SE ;

French, MB ;

Woods, SA ;

McGlade, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :33097-33104

[59] Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin [J].

Di Paolo, G ;

Pellegrini, L ;

Letinic, K ;

Cestra, G ;

Zoncu, R ;

Voronov, S ;

Chang, SH ;

Guo, J ;

Wenk, MR ;

De Camilli, P .

NATURE, 2002, 420 (6911) :85-89

[60] Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy [J].

Digman, Michelle A. ;

Brown, Claire M. ;

Horwitz, Alan R. ;

Mantulin, William W. ;

Gratton, Enrico .

BIOPHYSICAL JOURNAL, 2008, 94 (07) :2819-2831

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