Learning therapeutic lessons from metastasis suppressor proteins

被引：147

作者：

Smith, Steven Christopher

Theodorescu, Dan ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BREAST-CANCER METASTASIS; LYSOPHOSPHATIDIC ACID RECEPTOR; CIRCULATING TUMOR-CELLS; LYMPH-NODE METASTASIS; GENE-EXPRESSION; MEDROXYPROGESTERONE ACETATE; PROSTATE-CANCER; METRONOMIC CHEMOTHERAPY; BLADDER-CANCER; MELANOMA-CELLS;

D O I：

10.1038/nrc2594

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis suppressor proteins regulate multiple steps in the metastatic cascade, including cancer cell invasion, survival in the vascular and lymphatic circulation, and colonization of distant organ sites. Understanding the biology of metastasis suppressors provides valuable mechanistic insights that may translate to therapeutic opportunities. Several reports have explored novel strategies for restoring metastasis suppressor function, including gene transfer, induction of previously suppressed gene expression and exogenous administration of gene product. Pathways activated downstream of metastasis suppressor loss can also be targeted. Although none of these strategies are yet in routine clinical use, several are being tested preclinically and in clinical trials.

引用

页码：253 / 264

页数：12

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