meta-Aminoazobenzene as a thermo-insensitive photo-regulator of DNA-duplex formation

被引：27

作者：

Asanuma, H ^{[1
]}

Liang, XG ^{[1
]}

Komiyama, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 07期

基金：

日本学术振兴会;

关键词：

azo; azo compounds; isomerization; phosphoramidites; photochemistry;

D O I：

10.1016/S0040-4039(99)02233-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

meta-Aminoazobenzene has been introduced in the side chain of oligonucleotides as a photo-responsive molecule. Compared with the para-aminoazobenzene which was previously used, the thermal cis-->trans isomerization was much slower: the half-lives of the cis-isomers of m- and p-aminoazobenzene were 13.2 h and 20 min at 50 degrees C, respectively. By using the present oligonucleotides, duplex formation and dissociation was efficiently regulated on photo-irradiation without being disturbed by the thermal isomerization. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1055 / 1058

页数：4

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