Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action

被引：166

作者：

Manoharan, M ^{[1
]}

机构：

[1] ISIS Pharmaceut, Dept Med Chem, Carlsbad, CA 92008 USA

来源：

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1089/108729002760070849

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes the effect of conjugating small molecules and large biomacromolecules to antisense oligonucleotides to improve their therapeutic potential. In many cases, favorable changes in pharmacokinetic and pharmacodynamic properties were observed. Opportunities exist to change the terminating mechanism of antisense action or to enhance the RNase H mode of action via conjugate formation.

引用

页码：103 / 128

页数：26

共 139 条

[1]

AGRAWAL S, 1988, J DRUG TARGET, V5, P303

[2]

Alahari SK, 1996, MOL PHARMACOL, V50, P808

[3] The recognition and cleavage of RNA in the antisense oligo-RNA hybrid duplexes by RNase H [J].

Amirkhanov, NV ;

Zamaratski, E ;

Chattopadhyaya, J .

TETRAHEDRON LETTERS, 2001, 42 (03) :489-491

[4] Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties [J].

Antopolsky, M ;

Azhayeva, E ;

Tengvall, U ;

Auriola, S ;

Jääskeläinen, I ;

Rönkkö, S ;

Honkakoski, P ;

Urtti, A ;

Lönnberg, H ;

Azhayev, A .

BIOCONJUGATE CHEMISTRY, 1999, 10 (04) :598-606

[5] SYNTHESIS AND ANTIVIRAL ACTIVITY OF PEPTIDE-OLIGONUCLEOTIDE CONJUGATES PREPARED BY USING N-ALPHA-(BROMOACETYL)PEPTIDES [J].

ARAR, K ;

AUBERTIN, AM ;

ROCHE, AC ;

MONSIGNY, M ;

MAYER, R .

BIOCONJUGATE CHEMISTRY, 1995, 6 (05) :573-577

[6] Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates [J].

Astriab-Fisher, A ;

Sergueev, DS ;

Fisher, M ;

Shaw, BR ;

Juliano, RL .

BIOCHEMICAL PHARMACOLOGY, 2000, 60 (01) :83-90

[7] Oligonucleotide-europium complex conjugate designed to cleave the 5′ cap structure of the ICAM-1 transcript potentiates antisense activity in cells [J].

Baker, BF ;

Lot, SS ;

Kringel, J ;

Cheng-Flournoy, S ;

Villiet, P ;

Sasmor, HM ;

Siwkowski, AM ;

Chappell, LL ;

Morrow, JR .

NUCLEIC ACIDS RESEARCH, 1999, 27 (06) :1547-1551

[8] RIBOZYME MIMICS AS CATALYTIC ANTISENSE REAGENTS [J].

BASHKIN, JK ;

SAMPATH, U ;

FROLOVA, E .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1995, 54 (1-3) :43-56

[9]

BEAUCAGE SL, 1999, DNA ASPECTS MOL BIOL, P153

[10]

Bennett C F, 1999, Expert Opin Investig Drugs, V8, P237, DOI 10.1517/13543784.8.3.237

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