Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities

被引：274

作者：

Dogan, HN ^{[1
]}

Duran, A

Rollas, S

Sener, G

Uysal, MK

Gülen, D

机构：

[1] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-81010 Istanbul, Turkey

[2] Marmara Univ, Fac Pharm, Dept Pharmacol, TR-81010 Istanbul, Turkey

[3] Marmara Univ, Vocational Sch Hlth Related Professons, Dept Med Lab Technicians, TR-81010 Istanbul, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(02)00143-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two new series of 2.5-disubstituted-1,3.4-thiadiazoles were synthesized for their possible anticonvulsant. antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylene-tetrazole-induced convulsions in mice ranged from 0 to 90%, Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2893 / 2898

页数：6

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