Rho family GTPases as key regulators for neuronal network formation

被引：106

作者：

Negishi, M ^{[1
]}

Katoh, H ^{[1
]}

机构：

[1] Kyoto Univ, Mol Neurobiol Lab, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068502, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2002年 / 132卷 / 02期

关键词：

G protein; neuron; neuronal network; Rho;

D O I：

10.1093/oxfordjournals.jbchem.a003205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rho family GTPases act as transducers of signals from extracellular stimuli to the cytoskeleton and gene expression. Their actions are temporal and spatial determinants for cellular functions. The cellular functions of Rho family GTPases have been studied in fibroblasts and endothelial cells, and recent advances have revealed their roles in the regulation of neuronal network formation, including migration, neurite outgrowth, polarity, axon guidance, dendrite maturation and synapse formation. In addition, a significant number of X-linked mental retardation genes have been shown to encode components directly involved in signal transduction pathways of Rho family GTPases, underscoring the view that Rho family GTPases essentially participate in the neuronal network formation. In this review, we will overview current understanding of the functions of Rho family GTPases in neuronal network formation.

引用

页码：157 / 166

页数：10

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