Back to central tolerance

被引：154

作者：

Mathis, D ^{[1
]}

Benoist, C ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp,Dept Med, Joslin Diabet Ctr,Sect Immunol & Immunogenet, Boston, MA 02215 USA

来源：

IMMUNITY | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(04)00111-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.

引用

页码：509 / 516

页数：8

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