The Role of the Gastrointestinal Microbiota in Colorectal Cancer

被引:103
作者
Rowland, Ian R. [1 ]
机构
[1] Univ Reading, Dept Food Biosci, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England
关键词
Cancer; colorectal; carcinogens; genotoxins; bile acids; faecal water; DNA damage; BETA-GLUCURONIDASE ACTIVITY; N-NITROSO COMPOUNDS; COLON-CANCER; FECAL WATER; BILE-ACIDS; DIETARY FIBER; GERM-FREE; HIGH-RISK; CARCINOGENESIS; MICROFLORA;
D O I
10.2174/138161209788168191
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Both environmental and genetic factors contribute to cancers of the gastrointestinal tract including, the stomach, colon and rectum. The mechanisms associated with gastrointestinal cancer causation and prevention are largely unknown and the subject of much research. Many of the proposed mechanisms implicate the metabolic activities of the bacterial biota normally resident in the gastrointestinal tract. This review examines both the adverse and beneficial consequences of bacterial activity of the gastrointestinal tract focusing, in particularly on the stomach and large intestine. Studies on the role of the bacterial biota in colon carcinogenesis have also resulted in several useful biomarkers for use in human.
引用
收藏
页码:1524 / 1527
页数:4
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