Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev-Mediated RNA Transport

被引：15

作者：

Cao, Yuan ^{[1
]}

Liu, Xinyong ^{[1
]}

De Clercq, Erik ^{[2
]}

机构：

[1] Shandong Univ, Inst Med Chem, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

CURRENT HIV RESEARCH | 2009年 / 7卷 / 01期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

AIDS; HIV-1; transcription; inhibitors; Rev; RRE; antiviral; IMMUNODEFICIENCY-VIRUS TYPE-1; ARGININE-RICH MOTIF; NUCLEAR EXPORT; MESSENGER-RNA; RESPONSE ELEMENT; GENE-EXPRESSION; LEPTOMYCIN B; CELLULAR COFACTOR; SMALL MOLECULES; UNSPLICED RNA;

D O I：

10.2174/157016209787048564

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.

引用

页码：101 / 108

页数：8

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