New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

被引：86

作者：

Reddy, P. Prabhakar ^{[1
]}

Tiwari, Ashok K. ^{[2
]}

Rao, R. Ranga ^{[1
]}

Madhusudhana, K. ^{[2
]}

Rao, V. Rama Subba ^{[1
]}

Ali, Amtul Z. ^{[2
]}

Babu, K. Suresh ^{[1
]}

Rao, J. Madhusudana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Pharmacol, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 09期

关键词：

Hedychium spicatum; Labdane-type diterpenes; Spicatanol; Spicatanol methyl ether; Antihyperglycemic activity; alpha-Glucosidase inhibitory activity; POSTPRANDIAL HYPERGLYCEMIA;

D O I：

10.1016/j.bmcl.2009.03.045

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2562 / 2565

页数：4

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