Labdane-type diterpenes with inhibitory effects on increase in vascular permeability and nitric oxide production from Hedychium coronarium

被引：100

作者：

Matsuda, H ^{[1
]}

Morikawa, T ^{[1
]}

Sakamoto, Y ^{[1
]}

Toguchida, I ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0968-0896(02)00121-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The methanolic extract front the rhizome of Hedychium coronarium Was found to inhibit the increase in vascular permeability induced by acetic acid in mice and nitric oxide production in lipopolysaccharide-activated Mouse peritoneal macrophages. Front the methanolic extract, three new labdane-type diterpenes, hedychilactones A, 13, and C, were isolated together with six known diterpenes. The structures of hedychilactones were elucidated on the basis of chemical and physicochemical evidence. The diterpene constituents showed inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction. (C) 2002 Published by Elsevier Science Ltd.

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页码：2527 / 2534

页数：8

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