Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens

被引：233

作者：

Keyburn, Anthony L.

Sheedy, Scott A.

Ford, Mark E.

Williamson, Mark M.

Awad, Milena M.

Rood, Julian I.

Moore, Robert J.

机构：

[1] CSIRO, Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia

[2] Monash Univ, Australian Res Council, Ctr Excellence Struct & Funct Microbial Genom, Dept Microbiol, Clayton, Vic 3800, Australia

[3] Gribbles Vet Pathol, Clayton, Vic 3168, Australia

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 11期

关键词：

D O I：

10.1128/IAI.00806-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

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页码：6496 / 6500

页数：5

相关论文

共 48 条

[1] INTERACTION OF CLOSTRIDIUM-PERFRINGENS AND ITS TOXINS IN PRODUCTION OF NECROTIC ENTERITIS OF CHICKENS [J].

ALSHEIKHLY, F ;

TRUSCOTT, RB .

AVIAN DISEASES, 1977, 21 (02) :256-263

[2] PATHOLOGY OF NECROTIC ENTERITIS OF CHICKENS FOLLOWING INFUSION OF BROTH CULTURES OF CLOSTRIDIUM-PERFRINGENS INTO DUODENUM [J].

ALSHEIKHLY, F ;

TRUSCOTT, RB .

AVIAN DISEASES, 1977, 21 (02) :230-240

[3] PATHOLOGY OF NECROTIC ENTERITIS OF CHICKENS FOLLOWING INFUSION OF CRUDE TOXINS OF CLOSTRIDIUM-PERFRINGENS INTO DUODENUM [J].

ALSHEIKHLY, F ;

TRUSCOTT, RB .

AVIAN DISEASES, 1977, 21 (02) :241-255

[4] VIRULENCE STUDIES ON CHROMOSOMAL ALPHA-TOXIN AND THETA-TOXIN MUTANTS CONSTRUCTED BY ALLELIC EXCHANGE PROVIDE GENETIC-EVIDENCE FOR THE ESSENTIAL ROLE OF ALPHA-TOXIN IN CLOSTRIDIUM PERFRINGENS-MEDIATED GAS-GANGRENE [J].

AWAD, MM ;

BRYANT, AE ;

STEVENS, DL ;

ROOD, JI .

MOLECULAR MICROBIOLOGY, 1995, 15 (02) :191-202

[5] Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene [J].

Awad, MM ;

Ellemor, DM ;

Boyd, RL ;

Emmins, JJ ;

Rood, JI .

INFECTION AND IMMUNITY, 2001, 69 (12) :7904-7910

[6] EFFECTS OF EIMERIA-BRUNETTI INFECTION AND DIETARY ZINC ON EXPERIMENTAL INDUCTION OF NECROTIC ENTERITIS IN BROILER-CHICKENS [J].

BABA, E ;

FULLER, AL ;

GILBERT, JM ;

THAYER, SG ;

MCDOUGALD, LR .

AVIAN DISEASES, 1992, 36 (01) :59-62

[7] Immunohistochemical localization of Clostridium perfringens β2-toxin in the gastrointestinal tract of horses [J].

Bacciarini, LN ;

Boerlin, P ;

Straub, R ;

Frey, J ;

Gröne, A .

VETERINARY PATHOLOGY, 2003, 40 (04) :376-381

[8] NECROTIC ENTERITIS OF CHICKENS [J].

BAINS, BS .

AUSTRALIAN VETERINARY JOURNAL, 1968, 44 (01) :40-&

[9] A national police survey on the use of juvenile curfews [J].

Bannister, AJ ;

Carter, DL ;

Schafer, J .

JOURNAL OF CRIMINAL JUSTICE, 2001, 29 (03) :233-240

[10] Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates:: correlation of genotype with phenotype [J].

Bueschel, DM ;

Jost, BH ;

Billington, SJ ;

Trinh, HT ;

Songer, JG .

VETERINARY MICROBIOLOGY, 2003, 94 (02) :121-129

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