Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens

被引：233

作者：

Keyburn, Anthony L.

Sheedy, Scott A.

Ford, Mark E.

Williamson, Mark M.

Awad, Milena M.

Rood, Julian I.

Moore, Robert J.

机构：

[1] CSIRO, Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia

[2] Monash Univ, Australian Res Council, Ctr Excellence Struct & Funct Microbial Genom, Dept Microbiol, Clayton, Vic 3800, Australia

[3] Gribbles Vet Pathol, Clayton, Vic 3168, Australia

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 11期

关键词：

D O I：

10.1128/IAI.00806-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

引用

收藏

页码：6496 / 6500

页数：5

相关论文

共 48 条

[21] NECROTIC ENTERITIS IN TURKEYS [J].

GAZDZINSKI, P ;

JULIAN, RJ .

AVIAN DISEASES, 1992, 36 (03) :792-798

[22] Molecular and phenotypical characterization of Clostridium perfringens isolates from poultry flocks with different disease status [J].

Gholamiandekhordi, AR ;

Ducatelle, R ;

Heyndrickx, M ;

Haesebrouck, F ;

Van Immerseel, F .

VETERINARY MICROBIOLOGY, 2006, 113 (1-2) :143-152

[23] TOXIN PRODUCTION BY CLOSTRIDIUM-PERFRINGENS ISOLATED FROM BROILER-CHICKENS AND CAPERCAILLIES (TETRAO-UROGALLUS) WITH AND WITHOUT NECROTIZING ENTERITIS [J].

HOFSHAGEN, M ;

STENWIG, H .

AVIAN DISEASES, 1992, 36 (04) :837-843

[24]

LONG JR, 1973, CAN J COMP MED, V37, P302

[25] IDENTIFICATION AND MOLECULAR ANALYSIS OF A LOCUS THAT REGULATES EXTRACELLULAR TOXIN PRODUCTION IN CLOSTRIDIUM-PERFRINGENS [J].

LYRISTIS, M ;

BRYANT, AE ;

SLOAN, J ;

AWAD, MM ;

NISBET, IT ;

STEVENS, DL ;

ROOD, JI .

MOLECULAR MICROBIOLOGY, 1994, 12 (05) :761-777

[26] A role for the Clostridium perfringens β2 toxin in bovine enterotoxaemia? [J].

Manteca, C ;

Daube, G ;

Jauniaux, T ;

Linden, A ;

Pirson, V ;

Detilleux, J ;

Ginter, A ;

Coppe, P ;

Kaeckenbeeck, A ;

Mainil, JG .

VETERINARY MICROBIOLOGY, 2002, 86 (03) :191-202

[27] Identification of macrophage induced genes of Corynebacterium pseudotuberculosis by differential fluorescence induction [J].

McKean, S ;

Davies, J ;

Moore, R .

MICROBES AND INFECTION, 2005, 7 (13) :1352-1363

[28]

Meer RR, 1997, AM J VET RES, V58, P702

[29]

NAIRN M. E., 1967, AUST VET J, V43, P49, DOI 10.1111/j.1751-0813.1967.tb15062.x

[30] Analysis by pulsed-field gel electrophoresis of the genetic diversity among Clostridium perfringens isolates from chickens [J].

Nauerby, B ;

Pedersen, K ;

Madsen, M .

VETERINARY MICROBIOLOGY, 2003, 94 (03) :257-266

← 1 2 3 4 5 →