Electrical activity of artificial ion channels incorporated into planar lipid bilayers

被引：49

作者：

Voyer, N ^{[1
]}

Potvin, L ^{[1
]}

Rousseau, E ^{[1
]}

机构：

[1] UNIV SHERBROOKE,DEPT PHYSIOL & BIOPHYS,SHERBROOKE,PQ J1K 2R1,CANADA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1997年 / 08期

关键词：

D O I：

10.1039/a701060e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported, The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an alpha-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4, The latter showed typical single channel activity.

引用

页码：1469 / 1471

页数：3

共 20 条

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