Proteomics in nephrology: Current status and future directions

被引：66

作者：

Thongboonkerd, V ^{[1
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Fac Med,Siriraj Proteom Ctr, Off Res & Dev,Med Mol Biol Unit, Bangkok 10700, Thailand

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2004年 / 24卷 / 03期

关键词：

proteomics; proteome; proteomic analysis; mass spectrometry; physiology; nephrology; disease; biomarkers;

D O I：

10.1159/000079148

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Proteomics is one among various 'OMICS' fields that have been growing rapidly in the postgenomic era. During the past few years, proteomics has been extensively applied to several fields of medicine to better understand normal physiology, to define the pathophysiology of diseases, and to identify novel biomarkers and new therapeutic targets. This review focuses on current status and future directions of proteomics in the nephrology field. Recent studies of renal proteome, proteomes of individual intrarenal structures (i.e., glomerular, vascular, tubular, brush border membrane, mesangial, and podocyte proteomes), urinary proteome, and protein profiles in dialysate or ultrafiltrate removed by renal replacement therapy are summarized. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：360 / 378

页数：19

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