Mutational analysis of the hCDC4 gene in gastric carcinomas

被引：39

作者：

Lee, J. W. ^{[1
]}

Soung, Y. H. ^{[1
]}

Kim, H. J. ^{[1
]}

Park, W. S. ^{[1
]}

Nam, S. W. ^{[1
]}

Kim, S. H. ^{[1
]}

Lee, J. Y. ^{[1
]}

Yoo, N. J. ^{[1
]}

Lee, S. H. ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pathol, Seoul 137701, South Korea

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 14期

关键词：

hCDC4; mutation; gastric carcinoma; tumour suppressor gene;

D O I：

10.1016/j.ejca.2005.10.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

hCDC4, a ubiquitin ligase, plays a role in the control of cell cycle and chromosome stability. The hCDC4 gene is considered a tumour suppressor gene and is mutated in several human neoplasias, including colorectal and endometrial tumours. Data on the hCDC4 mutation in gastric cancer is, however, lacking. This study explored the possibility that hCDC4 mutation is involved in the development of gastric cancer. The hCDC4 gene in 162 gastric adenocarcinoma tissues was analysed for somatic mutations using a polymerase chain reaction-single strand conformation polymorphism assay. Overall, six hCDC4 mutations were found (3.7%), comprising four missense, one frameshift deletion and one nonsense mutation(s). It is notable that the hCDC4 mutations were found in early as well as in advanced gastric carcinomas. These data indicate that hCDC4 mutation occasionally occurs in gastric carcinomas and suggest that it might play a role in the development of some gastric carcinomas. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2369 / 2373

页数：5

共 23 条

[21] Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line [J].