Chiral aziridinyl radicals: An application to the synthesis of the core nucleus of FR-900482

被引：90

作者：

Ziegler, FE

Belema, M

机构：

[1] Sterling Chemistry Laboratory, Yale University, New Haven

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 04期

关键词：

D O I：

10.1021/jo961992n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric route to the core nucleus of the antitumor agent FR-900482 utilizes the cyclization of an aziridinyl radical into a functionalized indole nucleus. The route employs a selective Polonovski reaction and the Hootele-Dmitrienko rearrangement to install two oxygen atoms.

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页码：1083 / 1094

页数：12

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