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Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

被引：270
作者：
Mantovani, A
Allavena, P
Sica, A
机构：
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Univ Milan, Inst Gen Pathol, Ctr IDET, I-20133 Milan, Italy
来源：
EUROPEAN JOURNAL OF CANCER | 2004年 / 40卷 / 11期
关键词：
tumour-associated macrophages; polarised phagocyte populations; tumour progression;
D O I：
10.1016/j.ejca.2004.03.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：1660 / 1667
页数：8
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