Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

被引：270

作者：

Mantovani, A

Allavena, P

Sica, A

机构：

[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy

[2] Univ Milan, Inst Gen Pathol, Ctr IDET, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2004年 / 40卷 / 11期

关键词：

tumour-associated macrophages; polarised phagocyte populations; tumour progression;

D O I：

10.1016/j.ejca.2004.03.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1660 / 1667

页数：8

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