The evolution of Fox genes and their role in development and disease

被引：529

作者：

Hannenhalli, Sridhar ^{[1
,2
]}

Kaestner, Klaus H. ^{[1
,3
]}

机构：

[1] Univ Penn, Dept Genet, Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Penn Ctr Bioinformat, Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Diabet Obes & Metab, Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

FORKHEAD TRANSCRIPTION FACTOR; PROTEIN-KINASE B; WINGED HELIX/FORKHEAD PROTEINS; INSULIN-RESPONSE SEQUENCE; CAENORHABDITIS-ELEGANS; DNA-BINDING; PHOSPHOENOLPYRUVATE CARBOXYKINASE; EMBRYONIC EXPRESSION; GLUCOSE-HOMEOSTASIS; DEFINITIVE ENDODERM;

D O I：

10.1038/nrg2523

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The forkhead box (Fox) family of transcription factors, which originated in unicellular eukaryotes, has expanded over time through multiple duplication events, and sometimes through gene loss, to over 40 members in mammals. Fox genes have evolved to acquire a specialized function in many key biological processes. Mutations in Fox genes have a profound effect on human disease, causing phenotypes as varied as cancer, glaucoma and language disorders. We summarize the salient features of the evolution of the Fox gene family and highlight the diverse contribution of various Fox subfamilies to developmental processes, from organogenesis to speech acquisition.

引用

页码：233 / 240

页数：8

共 96 条

[61] Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver [J].