The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies

被引：69

作者：

Nwuba, RI

Sodeinde, O

Anumudu, CI

Omosun, YO

Odaibo, AB

Holder, AA

Nwagwu, M

机构：

[1] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

[2] Univ Ibadan, Univ Coll Hosp, Dept Paediat, Ibadan, Nigeria

[3] Univ Ibadan, Dept Zool, Cellular Parasitol Programme, Ibadan, Nigeria

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/IAI.70.9.5328-5331.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSPI-based vaccines.

引用

收藏

页码：5328 / 5331

页数：4

相关论文

共 18 条

[1] SECONDARY PROCESSING OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP1) BY A CALCIUM-DEPENDENT MEMBRANE-BOUND SERINE PROTEASE - SHEDDING OF MSP133 AS A NONCOVALENTLY ASSOCIATED COMPLEX WITH OTHER FRAGMENTS OF THE MSP1 [J].

BLACKMAN, MJ ;

HOLDER, AA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 50 (02) :307-316

[2]

BLACKMAN MJ, 1994, METHOD CELL BIOL, V45, P213

[3] A SINGLE FRAGMENT OF A MALARIA MEROZOITE SURFACE PROTEIN REMAINS ON THE PARASITE DURING RED-CELL INVASION AND IS THE TARGET OF INVASION-INHIBITING ANTIBODIES [J].

BLACKMAN, MJ ;

HEIDRICH, HG ;

DONACHIE, S ;

MCBRIDE, JS ;

HOLDER, AA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :379-382

[4] ANTIBODIES INHIBIT THE PROTEASE-MEDIATED PROCESSING OF A MALARIA MEROZOITE SURFACE PROTEIN [J].

BLACKMAN, MJ ;

SCOTTFINNIGAN, TJ ;

SHAI, S ;

HOLDER, AA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :389-393

[5] ANTIBODIES THAT PROTECT HUMANS AGAINST PLASMODIUM-FALCIPARUM BLOOD STAGES DO NOT ON THEIR OWN INHIBIT PARASITE GROWTH AND INVASION INVITRO, BUT ACT IN COOPERATION WITH MONOCYTES [J].

BOUHAROUNTAYOUN, H ;

ATTANATH, P ;

SABCHAREON, A ;

CHONGSUPHAJAISIDDHI, T ;

DRUILHE, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1633-1641

[6] EXPRESSION OF THE 19-KILODALTON CARBOXY-TERMINAL FRAGMENT OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 IN ESCHERICHIA-COLI AS A CORRECTLY FOLDED PROTEIN (VOL 64, PG 165, 1994) [J].

BURGHAUS, PA ;

HOLDER, AA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 67 (02) :343-343

[7] EXPRESSION OF THE 19-KILODALTON CARBOXY-TERMINAL FRAGMENT OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 IN ESCHERICHIA-COLI AS A CORRECTLY FOLDED PROTEIN [J].

BURGHAUS, PA ;

HOLDER, AA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 64 (01) :165-169

[8] NATURALLY ACQUIRED HUMAN-ANTIBODIES WHICH RECOGNIZE THE FIRST EPIDERMAL GROWTH FACTOR-LIKE MODULE IN THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 DO NOT INHIBIT PARASITE GROWTH IN-VITRO [J].

CHAPPEL, JA ;

EGAN, AF ;

RILEY, EM ;

DRUILHE, P ;

HOLDER, AA .

INFECTION AND IMMUNITY, 1994, 62 (10) :4488-4494

[9] Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria [J].

Dodoo, D ;

Theander, TG ;

Kurtzhals, JAL ;

Koram, K ;

Riley, E ;

Akanmori, BD ;

Nkrumah, FK ;

Hviid, L .

INFECTION AND IMMUNITY, 1999, 67 (05) :2131-2137

[10] Human antibodies to the 19 kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro [J].

Egan, AF ;

Burghaus, P ;

Druilhe, P ;

Holder, AA ;

Riley, EM .

PARASITE IMMUNOLOGY, 1999, 21 (03) :133-139