Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection

被引：127

作者：

Takizawa, T ^{[1
]}

Ohashi, K ^{[1
]}

Nakanishi, Y ^{[1
]}

机构：

[1] KANAZAWA UNIV,FAC PHARMACEUT SCI,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 11期

关键词：

D O I：

10.1128/JVI.70.11.8128-8132.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We reported previously that influenza, virus infection induces the apoptotic death of HeLa cells associated with activation of the Fas gene. In this report, we show that transfection with a PKR having a point mutation in the catalytic domain of K at 296 to R suppressed both the augmented expression of Fas and cell death by influenza virus infection. These results suggested the involvement of PKR in influenza virus-induced cell death.

引用

页码：8128 / 8132

页数：5

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