Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

被引：72

作者：

Comini Frota, Elizabeth Regina ^{[1
]}

Rodrigues, David Henrique ^{[2
]}

Donadi, Eduardo Antonio ^{[3
]}

Brum, Doralina G. ^{[4
]}

Kaimen Maciel, Damacio Ramon ^{[5
]}

Teixeira, Antonio Lucio ^{[1
,2
,6
]}

机构：

[1] Univ Fed Minas Gerais, Univ Hosp, Neurol Unit, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunopharmacol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Div Immunol, Dept Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurol, BR-14049900 Ribeirao Preto, SP, Brazil

[5] Univ Estadual Londrina, Hlth Sci Ctr, Dept Med, BR-86038440 Londrina, PR, Brazil

[6] Univ Fed Minas Gerais, Sch Med, Dept Internal Med, BR-30130100 Belo Horizonte, MG, Brazil

来源：

NEUROSCIENCE LETTERS | 2009年 / 460卷 / 02期

关键词：

Neurotrophins; Brain derived neurotrophic factor; Multiple sclerosis; Neuroprotection; IMMUNE; IMPAIRMENT; SECRETION; CELLS; SERUM; MS;

D O I：

10.1016/j.neulet.2009.05.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 132

页数：3

共 22 条

[1]

Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: Reversal by glatiramer acetate [J].

Azoulay, D ;

Vachapova, V ;

Shihman, B ;

Miler, A ;

Karni, A .

JOURNAL OF NEUROIMMUNOLOGY, 2005, 167 (1-2) :215-218

[2]

Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection [J].

Azoulay, David ;

Urshansky, Natali ;

Karni, Arnon .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 195 (1-2) :186-193

[3]

The immunology of multiple sclerosis [J].

Bar-Or, Amit .

SEMINARS IN NEUROLOGY, 2008, 28 (01) :29-45

[4]

The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage [J].

Brück, W .

JOURNAL OF NEUROLOGY, 2005, 252 (Suppl 5) :V3-V9

[5]

Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis [J].

Castellano, Vanessa ;

White, Lesley J. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 269 (1-2) :85-91

[6]

Reconsidering clinical outcomes in Multiple Sclerosis: Relapses, impairment, disability and beyond [J].

D'Souza, M. ;

Kappos, L. ;

Czaplinski, A. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 274 (1-2) :76-79

[7]

Ebers GC, 2000, NEUROL SCI S, V21, P815

[8]

New concepts in the immunopathogenesis of multiple sclerosis [J].

Hemmer, B ;

Archelos, JJ ;

Hartung, HP .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (04) :291-301

[9]

The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis [J].

Hohlfeld, R ;

Kerschensteiner, M ;

Stadelmann, C ;

Lassmann, H ;

Wekerle, H .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 107 (02) :161-166

[10]

Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases [J].

Kerschensteiner, M ;

Stadelmann, C ;

Dechant, G ;

Wekerle, H ;

Hohlfeld, R .

ANNALS OF NEUROLOGY, 2003, 53 (03) :292-304

← 1 2 3 →