85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain

被引:104
作者
Rintala, J
Seemann, R
Chandrasekaran, K
Rosenberger, TA
Chang, L
Contreras, MA
Rapoport, SI
Chang, MCJ
机构
[1] NIA, Sect Brain Physiol & Metabol, NIH, Bethesda, MD 20892 USA
[2] Univ Maryland, Dept Anesthesiol, Sch Med, Teaching Facil, Baltimore, MD 21201 USA
关键词
brain; chronic lithium; phospholipids; signal transduction;
D O I
10.1097/00001756-199912160-00030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE mechanism by which chronic lithium exerts its therapeutic effect in brains of bipolar patients is not known. One possibility, suggested by our demonstration in the rat brain, is that chronic lithium inhibits turnover of arachidonic acid (AA) by reducing the activity of an AA-specific phospholipase A2 (PLA2). To test this further, mRNA levels of two AA-specific PLA2s, cytosolic PLA2 (cPLA2) type IV and intracellular PLA2 (iPLA2) type VIII, and protein level of cPLA2 were quantified in the brain of rats given lithium for 6 weeks. Chronic lithium markedly reduced brain mRNA and protein level of cPLA2, but had no effect on mRNA level of iPLA2. These results suggest that the final common path effect of chronic lithium administration is to reduce turnover of AA in brain by down-regulating cPLA2. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:3887 / 3890
页数:4
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