Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease

被引:71
作者
Tittle, TV
Weinberg, AD
Steinkeler, CN
Maziarz, RT
机构
[1] OREGON HLTH SCI UNIV,DIV HEMATOL & MED ONCOL,PORTLAND,OR 97201
[2] PROVIDENCE MED CTR,EARLE A CHILES RES INST,PORTLAND,OR
[3] OREGON HLTH SCI UNIV,DIV HEMATOL & MED ONCOL,PORTLAND,OR 97201
[4] VET AFFAIRS MED CTR,PORTLAND,OR
关键词
D O I
10.1182/blood.V89.12.4652
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The OX-40 molecule is expressed on the surface of recently activated T lymphocytes, The presence of OX-40 on CD4(+) T cells was analyzed in a rat haplo-identical (parental --> F1) bone marrow transplant model of acute graft-versus-host disease (aGVHD), Increased numbers of activated CD4(+) T cells that expressed the OX-40 antigen were detected in peripheral blood soon after transplantation before the earliest sign of disease. The peak of OX-40 expression occurred 12 days posttransplantation with a range of 18% to 36% of circulating T cells and remained 10-fold above background, never returning to baseline, A slight increase in OX-40 expression (range, 1% to 6%) was also detected on peripheral blood lymphocytes from control syngeneic Fl --> Fl recipients, OX-40(+) T cells were isolated from spleen, skin, lymph node, end liver tissue of rats undergoing aGVHD, but not in syngeneic transplants, OX-40(+) T cells isolated from these tissues were of donor origin and were shown to be alloreactive, These data raise the possibility of using the OX-40 antibody to detect and deplete selectively the T cells that cause aGVHD. (C) 1997 by The American Society of Hematology.
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页码:4652 / 4658
页数:7
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