Bone morphogenetic protein-4 expression in the adult rat brain

被引：35

作者：

Mikawa, Sumiko ^{[1
]}

Wang, Cong ^{[1
]}

Sato, Kohji ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Anat & Neurosci, Shizuoka 4313192, Japan

来源：

JOURNAL OF COMPARATIVE NEUROLOGY | 2006年 / 499卷 / 04期

关键词：

dendrite; neuropil; immunohistochemistry;

D O I：

10.1002/cne.21125

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bone morphogenetic protein-4 (BMP4) is a member of the transforming growth factor-beta (TGF-beta) superfamily and plays important roles in multiple biological events. Although BMP4 expression has been well described in the early development of the central nervous system (CNS), little information is available on its expression in the adult CNS. Therefore, we investigated BMP4 expression in the adult rat CNS by using immunohistochemistry. BMP4 is intensely expressed in most neurons and their dendrites. In addition, intense BMP4 expression was also observed in the neuropil of the gray matters where high plasticity is reported, such as the molecular layer of the cerebellum and the superficial layer of the superior colliculus. Furthermore, we found that astrocytes also express BMP4 protein. These data indicate that BMP4 is more widely expressed throughout the adult CNS than previously reported, and its continued abundant expression in the adult brain strongly supports the idea that BMP4 plays pivotal roles also in the adult brain.

引用

页码：613 / 625

页数：13

共 32 条

[1] Blocked MAP kinase activity selectively enhances neurotrophic growth responses [J].

Althini, S ;

Usoskin, D ;

Kylberg, A ;

Kaplan, PL ;

Ebendal, T .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 25 (02) :345-354

[2] Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia [J].

Charytoniuk, DA ;

Traiffort, E ;

Pinard, E ;

Issertial, O ;

Seylaz, J ;

Ruat, M .

NEUROSCIENCE, 2000, 100 (01) :33-43

[3] BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation [J].

Cho, KWY ;

Blitz, IL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (04) :443-449

[4] Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles [J].

Crossley, PH ;

Martinez, S ;

Ohkubo, Y ;

Rubenstein, JLR .

NEUROSCIENCE, 2001, 108 (02) :183-206

[5] Spatial and temporal patterns of expression of Noggin and BMP4 in embryonic and postnatal rat hippocampus [J].

Fan, XT ;

Xu, HW ;

Cai, WQ ;

Yang, Z ;

Zhang, JH .

DEVELOPMENTAL BRAIN RESEARCH, 2003, 146 (1-2) :51-58

[6] Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus [J].

Fujino, K ;

Oertel, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :265-270

[7]

Furuta Y, 1997, DEVELOPMENT, V124, P2203

[8] Neurogenesis in the adult brain [J].

Gage, FH .

JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :612-613

[9] Induction of the candidate-plasticity NGFI-A protein in the adult rat superior colliculus after visual stimulation [J].

Giraldi-Guimaraes, A ;

Mendez-Otero, R .

MOLECULAR BRAIN RESEARCH, 2005, 133 (02) :242-252

[10] Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment [J].

Gomes, WA ;

Mehler, MF ;

Kessler, JA .

DEVELOPMENTAL BIOLOGY, 2003, 255 (01) :164-177

← 1 2 3 4 →