Platycodin D Inhibits Osteoclastogenesis by Repressing the NFATc1 and MAPK Signaling Pathway

被引：41

作者：

Choi, Jae Ho ^{[1
]}

Han, Younho ^{[2
,3
]}

Kim, Yong An ^{[1
]}

Jin, Sun Woo ^{[1
]}

Lee, Gi Ho ^{[1
]}

Jeong, Hyung Min ^{[2
,3
]}

Lee, Hyun Sun ^{[4
]}

Chung, Young Chul ^{[5
]}

Lee, Young Chun ^{[6
]}

Kim, Eun Ju ^{[6
]}

Lee, Kwang Youl ^{[2
,3
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea

[2] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[3] Chonnam Natl Univ, Res Inst Drug Dev, Kwangju 500757, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Daejeon, South Korea

[5] Int Univ Korea, Dept Food Sci, Jinju, South Korea

[6] Jangsaeng Doraji Co Ltd, Jangsaeng Doraji Res Inst Biotechnol, Jinju, South Korea

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 04期

关键词：

PLATYCODON GRANDIFLORUM; SAPONINS; PLATYCODIN D; BONE LOSS; OSTEOCLAST; OVARIECTOMY; NF-KAPPA-B; STIMULATE OSTEOBLAST DIFFERENTIATION; HEPATIC LIPOGENESIS; RUNX2; ACTIVATION; HEPG2; CELLS; P38; MAPK; GRANDIFLORUM; SAPONINS; BONE; ROOTS;

D O I：

10.1002/jcb.25763

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) are reported to have many pharmacological activities. In our latest research, CKS was proven to have a significant osteogenic effect. However, the detail molecular mechanism of CKS on osteoclastic differentiation has not been fully investigated. Administration of CKS considerably reduced OVX-induced bone loss, and ameliorated the reduction in plasma levels of alkaline phosphatase, calcium, and phosphorus observed in OVX mice. CKS also repressed the deterioration of bone trabecular microarchitecture. Interestingly, platycodin D, the most abundant and major pharmacological constituent of triterpenoid CKS, inhibited receptor activator of NF-kappa B ligand (RANKL)-induced activation of NF-kappa B, and ERK and p38 MAPK, ultimately repressing osteoclast differentiation. OVX-induced bone turnover was attenuated by CKS, possibly via repression of osteoclast differentiation by platycodin D, the active component of CKS. Platycodin D can be regarded as an antiosteoporotic candidate for treatment of osteoporosis diseases. (C) 2016 Wiley Periodicals, Inc.

引用

页码：860 / 868

页数：9

共 37 条

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