Saponins, Especially Platyconic Acid A, from Platycodon grandiflorum Reduce Airway Inflammation in Ovalbumin-Induced Mice and PMA-Exposed A549 Cells

被引：33

作者：

Choi, Jae Ho ^{[1
]}

Jin, Sun Woo ^{[1
]}

Kim, Hyung Gyun ^{[1
]}

Choi, Chul Yung ^{[2
]}

Lee, Hyun Sun ^{[3
]}

Ryu, Shi Yong ^{[4
]}

Chung, Young Chul ^{[5
]}

Hwang, Young Jung ^{[5
]}

Um, Yeon Ji ^{[6
]}

Jeong, Tae Cheon ^{[6
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Dept Toxicol, Taejon 305764, South Korea

[2] Jeollanamdo Inst Nat Resources Res, Jeollanamdo 529851, South Korea

[3] Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Taejon 301724, South Korea

[4] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[5] Int Univ Korea, Dept Food Sci, Jinju 660759, South Korea

[6] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2015年 / 63卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Platycodon grandiflorum; saponins; airway inflammation; platyconic acid A; NF-kappa B; INDUCED HEPATOTOXICITY; ALLERGIC-ASTHMA; MURINE MODEL; MAST-CELLS; ROOTS; INHIBITION; EXPRESSION; SUPPRESSION; ACTIVATION; PROTEIN;

D O I：

10.1021/jf5043954

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number, IgE, Th1/Th2 cytokines, and MCP-1 chemokine secretion in bronchoalveolar lavage fluid. Also, ovalbumin-increased MUC5AC, MMP-2/9, and TIMP-1/-2 mRNA expression, NF-kappa B activation, leukocytes recruitment, and mucus secretion were inhibited by CKS treatment. Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 +/- 0.2 to 1.1 +/- 0.1) by inhibiting NF-kappa B activation (from 2.3 +/- 0.2 to 1.2 +/- 0.1) via Akt (from 3.7 +/- 0.3 to 2.1 +/- 0.2) (p < 0.01) in A549 cells. Therefore, we demonstrate that CKS or PA suppressed the development of respiratory inflammation, hyperresponsiveness, and remodeling by reducing allergic responses, and they may be potential herbal drugs for allergen-induced respiratory disease prevention.

引用

页码：1468 / 1476

页数：9

共 46 条

[1]

Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-KB activation in RAW 264.7 cells [J].