Topical application of Pleurotus eryngii extracts inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance

被引：45

作者：

Choi, Jae Ho ^{[1
]}

Kim, Hyung Gyun ^{[1
]}

Jin, Sun Woo ^{[1
]}

Han, Eun Hee ^{[1
]}

Khanal, Tilak ^{[1
]}

Do, Minh Truong ^{[1
]}

Hwang, Yong Pil ^{[1
,2
]}

Choi, Jun Min ^{[3
]}

Chun, Sung-Sik ^{[3
]}

Chung, Young Chul ^{[3
]}

Jeong, Tae Cheon ^{[4
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Dept Toxicol, Coll Pharm, Taejon 305764, South Korea

[2] Int Univ Korea, Dept Pharmaceut Engn, Jinju 660759, South Korea

[3] Int Univ Korea, Dept Food Sci, Jinju 660759, South Korea

[4] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 53卷

关键词：

Pleurotus eryngii; Atopic dermatitis; IgE; TARC; NC/Nga mice; SKIN-LESIONS; T-CELLS; STRATUM-CORNEUM; MOUSE MODEL; MAST-CELLS; MUSHROOM; IGE; ACTIVATION; EXPRESSION; PROLIFERATION;

D O I：

10.1016/j.fct.2012.11.025

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Pleurotus eryngii is a nutritional and medicinal food rich in polysaccharides that enhance the host immune system as a response to various diseases. The present study investigated the effects of P. eryngii extracts (PEE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 2,4-dinitrochlorobenzene (DNCB). We evaluated skin dermatitis severity, ear thickness, histopathological examination, and cytokines level in DNCB-applied mice treated with PEE. Continuous treatment of PEE inhibited the development of the AD-like skin lesions. PEE suppressed DNCB-induced dermatitis severity, serum level of IgE and thymus and activation-regulated chemokine (TARC), and mRNA expression of TNF-alpha, INF-gamma, IL-4, IL-5, and IL-13 in mice. In addition, PEE reduced thickness of the dermis and dermal infiltration of inflammatory cells and mast cells in histopathological examination. These results indicate that PEE inhibits allergic contact dermatitis through the modulating of T helper (Th)1 and Th2 responses and diminishing the inflammatory cells and mast cells infiltration in the skin lesions in NC/Nga mice. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：38 / 45

页数：8

共 60 条

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