Driving fast-spiking cells induces gamma rhythm and controls sensory responses

被引:1880
作者
Cardin, Jessica A. [1 ,2 ]
Carlen, Marie [3 ,4 ]
Meletis, Konstantinos [3 ,4 ]
Knoblich, Ulf [1 ]
Zhang, Feng [5 ]
Deisseroth, Karl [5 ]
Tsai, Li-Huei [3 ,4 ,6 ]
Moore, Christopher I. [1 ]
机构
[1] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA
[2] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA
[3] MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
[4] Broad Inst Harvard & Massachusetts Inst Technol, Stanley Ctr Psychiat Res, Cambridge, MA 02139 USA
[5] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[6] Howard Hughes Med Inst, Cambridge, MA 02139 USA
基金
美国国家科学基金会;
关键词
NEURONAL SYNCHRONIZATION; ELECTRICAL SYNAPSES; CORTICAL NETWORKS; FAST OSCILLATIONS; CORTEX; INTERNEURONS; BRAIN; SCHIZOPHRENIA; GENERATION; ATTENTION;
D O I
10.1038/nature08002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
引用
收藏
页码:663 / U63
页数:6
相关论文
共 33 条
  • [11] Rapid feature selective neuronal synchronization through correlated latency shifting
    Fries, P
    Neuenschwander, S
    Engel, AK
    Goebel, R
    Singer, W
    [J]. NATURE NEUROSCIENCE, 2001, 4 (02) : 194 - 200
  • [12] Modulation of oscillatory neuronal synchronization by selective visual attention
    Fries, P
    Reynolds, JH
    Rorie, AE
    Desimone, R
    [J]. SCIENCE, 2001, 291 (5508) : 1560 - 1563
  • [13] The gamma cycle
    Fries, Pascal
    Nikolic, Danko
    Singer, Wolf
    [J]. TRENDS IN NEUROSCIENCES, 2007, 30 (07) : 309 - 316
  • [14] A network of fast-spiking cells in the neocortex connected by electrical synapses
    Galarreta, M
    Hestrin, S
    [J]. NATURE, 1999, 402 (6757) : 72 - 75
  • [15] STIMULUS-SPECIFIC NEURONAL OSCILLATIONS IN ORIENTATION COLUMNS OF CAT VISUAL-CORTEX
    GRAY, CM
    SINGER, W
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) : 1698 - 1702
  • [16] Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
    Hasenstaub, A
    Shu, YS
    Haider, B
    Kraushaar, U
    Duque, A
    McCormick, DA
    [J]. NEURON, 2005, 47 (03) : 423 - 435
  • [17] A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    Hippenmeyer, S
    Vrieseling, E
    Sigrist, M
    Portmann, T
    Laengle, C
    Ladle, DR
    Arber, S
    [J]. PLOS BIOLOGY, 2005, 3 (05) : 878 - 890
  • [18] Hubbard JI., 1969, ELECTROPHYSIOLOGICAL
  • [19] Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice
    Huber, Daniel
    Petreanu, Leopoldo
    Ghitani, Nima
    Ranade, Sachin
    Hromadka, Tomas
    Mainen, Zach
    Svoboda, Karel
    [J]. NATURE, 2008, 451 (7174) : 61 - U7
  • [20] High-Resolution Labeling and Functional Manipulation of Specific Neuron Types in Mouse Brain by Cre-Activated Viral Gene Expression
    Kuhlman, Sandra J.
    Huang, Z. Josh
    [J]. PLOS ONE, 2008, 3 (04):