The involvement of RNA in ribosome function

被引：129

作者：

Moore, PB

Steitz, TA

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[3] Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

NATURE | 2002年 / 418卷 / 6894期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/418229a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ribosome is a particle made of RNA and protein that is found in abundance in all cells that are actively making protein. It catalyses the messenger RNA-directed synthesis of proteins. Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution.

引用

收藏

页码：229 / 235

页数：7

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共 63 条

[1] Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle [J].

Agrawal, RK ;

Spahn, CMT ;

Penczek, P ;

Grassucci, RA ;

Nierhaus, KH ;

Frank, J .

JOURNAL OF CELL BIOLOGY, 2000, 150 (03) :447-459

[2] Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome [J].

Agrawal, RK ;

Penczek, P ;

Grassucci, RA ;

Li, YH ;

Leith, A ;

Nierhaus, KH ;

Frank, J .

SCIENCE, 1996, 271 (5251) :1000-1002

[3] EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome [J].

Agrawal, RK ;

Heagle, AB ;

Penczek, P ;

Grassucci, RA ;

Frank, J .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (07) :643-647

[4] Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation [J].

Agrawal, RK ;

Linde, J ;

Sengupta, J ;

Nierhaus, KH ;

Frank, J .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 311 (04) :777-787

[5] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[6] Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Capel, M ;

Moore, PB ;

Steitz, TA .

NATURE, 1999, 400 (6747) :841-847

[7] A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition [J].

Bayfield, MA ;

Dahlberg, AE ;

Schulmeister, U ;

Dorner, S ;

Barta, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10096-10101

[8] Architecture of the protein-conducting channel associated with the translating 80S ribosome [J].

Beckmann, R ;

Spahn, CMT ;

Eswar, N ;

Helmers, J ;

Penczek, PA ;

Sali, A ;

Frank, J ;

Blobel, G .

CELL, 2001, 107 (03) :361-372

[9] Alignment of conduits for the nascent polypeptide chain in the Ribosome-Sec61 complex [J].

Beckmann, R ;

Bubeck, D ;

Grassucci, R ;

Penczek, P ;

Verschoor, A ;

Blobel, G ;

Frank, J .

SCIENCE, 1997, 278 (5346) :2123-2126

[10] NASCENT POLYPEPTIDE-CHAINS EMERGE FROM THE EXIT DOMAIN OF THE LARGE RIBOSOMAL-SUBUNIT - IMMUNE MAPPING OF THE NASCENT CHAIN [J].

BERNABEU, C ;

LAKE, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3111-3115

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