Risk of dementia after anaesthesia and surgery

被引:117
作者
Chen, Pin-Liang [1 ]
Yang, Chih-Wen [2 ,3 ]
Tseng, Yi-Kuan [4 ]
Sun, Wei-Zen [5 ]
Wang, Jane-Ling [6 ]
Wang, Shuu-Jiun [3 ,7 ]
Oyang, Yen-Jen [1 ,8 ]
Fuh, Jong-Ling [3 ,7 ]
机构
[1] Natl Taiwan Univ, Dept Comp Sci & Informat Engn, Taipei 10764, Taiwan
[2] Taipei Vet Gen Hosp, Dept Neurol, Su Ao & Yuanshan Branch, Taipei, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[4] Natl Cent Univ, Grad Inst Stat, Jhongli, Taiwan
[5] Natl Taiwan Univ Hosp, Dept Anaesthesiol, Taipei, Taiwan
[6] Univ Calif Davis, Dept Stat, Davis, CA 95616 USA
[7] Taipei Vet Gen Hosp, Dept Neurol, Neurol Inst, Taipei, Taiwan
[8] Natl Taiwan Univ, Grad Inst Biomed Elect & Bioinformat, Taipei 10764, Taiwan
基金
美国国家卫生研究院;
关键词
ALZHEIMERS-DISEASE; GENERAL-ANESTHESIA; COGNITIVE DYSFUNCTION; NONCARDIAC SURGERY; SPATIAL MEMORY; EXPOSURE; ISOFLURANE; OLIGOMERIZATION; INFLAMMATION; IMPAIRMENT;
D O I
10.1192/bjp.bp.112.119610
中图分类号
R749 [精神病学];
学科分类号
100204 [神经病学];
摘要
Background The potential relationship between anaesthesia, surgery and onset of dementia remains elusive. Aims To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia. Method The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia. Results Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio=1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia. Conclusions The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.
引用
收藏
页码:188 / 193
页数:6
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