MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

被引：62

作者：

Cortez, Maria Angelica ^{[2
]}

Calin, George Adrian ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Unit 422, Houston, TX 77030 USA

[2] Fac Med Ribeirao Preto, Dept Genet, Sao Paulo, Brazil

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2009年 / 9卷 / 06期

关键词：

cancer; microRNA; plasma; serum; NUCLEAR EXPORT; CIRCULATING MICRORNAS; GENE-EXPRESSION; MESSENGER-RNAS; IN-VIVO; CANCER; BIOMARKERS; SIGNATURES; CARCINOMA; TARGETS;

D O I：

10.1517/14712590902932889

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.

引用

页码：703 / 711

页数：9

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