A hydrophilic three side-chained triazatruxene as a new strong and selective G-quadruplex ligand

被引：50

作者：

Ginnari-Satriani, Luca ^{[1
]}

Casagrande, Valentina ^{[1
]}

Bianco, Armandodoriano ^{[1
]}

Ortaggi, Giancarlo ^{[1
]}

Franceschin, Marco ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 12期

关键词：

IONIZATION MASS-SPECTROMETRY; PERYLENE DERIVATIVES; TELOMERASE INHIBITION; CORONENE DERIVATIVES; DNA STRUCTURES; NUCLEIC-ACIDS; ESI-MS; COMPLEXES; AFFINITY; BINDING;

D O I：

10.1039/b904723a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new hydrosoluble triazatruxene derivative (AZATRUX) is reported to selectively bind to G-quadruplex DNA, as derived by ESI-MS measurements and competition experiments.

引用

页码：2513 / 2516

页数：4

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