Tumor metastasis: mechanistic insights and clinical challenges

被引：1746

作者：

Steeg, Patricia S. ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, Lab Mol Pharmacol, Womens Canc Sect,NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 08期

关键词：

ENDOTHELIAL GROWTH-FACTOR; BREAST-CANCER CELLS; HUMAN PANCREATIC-CANCER; MATRIX-METALLOPROTEINASE INHIBITORS; MAMMARY-CARCINOMA CELLS; FOCAL-ADHESION KINASE; IN-VIVO; COLORECTAL-CANCER; NUDE-MICE; LIVER METASTASIS;

D O I：

10.1038/nm1469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastatic disease is the primary cause of death for most cancer patients. Complex and redundant pathways involving the tumor cell and the microenvironment mediate tumor invasion at the primary site, survival and arrest in the bloodstream, and progressive outgrowth at a distant site. Understanding these pathways and their dynamic interactions will help identify promising molecular targets for cancer therapy and key obstacles to their clinical development.

引用

页码：895 / 904

页数：10

共 165 条

[1] Therapeutic implications of cancer stem cells [J].

Al-Hajj, M ;

Becker, MW ;

Wichal, M ;

Weissman, I ;

Clarke, MF .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) :43-47

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] Self-renewal and solid tumor stem cells [J].

Al-Hajj, M ;

Clarke, MF .

ONCOGENE, 2004, 23 (43) :7274-7282

[4] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].

Al-Mehdi, AB ;

Tozawa, K ;

Fisher, AB ;

Shientag, L ;

Lee, A ;

Muschel, RJ .

NATURE MEDICINE, 2000, 6 (01) :100-102

[5] ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model [J].

Arao, T ;

Yanagihara, K ;

Takigahira, M ;

Takeda, M ;

Koizumi, F ;

Shiratori, Y ;

Nishio, K .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (02) :483-489

[6] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[7] Chemokine biology in cancer [J].

Balkwill, F .

SEMINARS IN IMMUNOLOGY, 2003, 15 (01) :49-55

[8] Getitinib (ZD1839, Iressa®) in non-small-cell lung cancer:: a review of clinical trials from a daily practice perspective [J].

Barlési, F ;

Tchouhadjian, C ;

Doddoli, C ;

Villani, P ;

Greillier, L ;

Kleisbauer, JP ;

Thomas, P ;

Astoul, P .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2005, 19 (03) :385-393

[9] Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma [J].

Bendell, JC ;

Domchek, SM ;

Burstein, HJ ;

Harris, L ;

Younger, J ;

Kuter, I ;

Bunnell, C ;

Rue, M ;

Gelman, R ;

Winer, E .

CANCER, 2003, 97 (12) :2972-2977

[10] Met, metastasis, motility and more [J].

Birchmeier, C ;

Birchmeier, W ;

Gherardi, E ;

Vande Woude, GF .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (12) :915-925

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