Rapid multi-residue analysis of antibiotics in muscle by liquid chromatography-tandem mass spectrometry

被引：92

作者：

Granelli, K. ^{[1
]}

Elgerud, Chyistina ^{[1
]}

Lundstroem, Asa ^{[1
]}

Ohlsson, Anita ^{[1
]}

Sjoebery, Pernilla ^{[1
]}

机构：

[1] Natl Food Adm Toxicol Lab, Chem Div 1, SE-75126 Uppsala, Sweden

来源：

ANALYTICA CHIMICA ACTA | 2009年 / 637卷 / 1-2期

关键词：

Antibiotics; Tetracyclines; Sulfonamides; Quinolones; beta-Lactams; Macrolides; Muscle; Liquid chromatography-tandem mass spectrometry; Veterinary drugs; Multi-residue; VETERINARY DRUGS; KIDNEY; BOVINE;

D O I：

10.1016/j.aca.2008.08.025

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A way of carrying out simple and rapid multi-residue analysis of antibiotics in porcine and bovine muscle by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is described. The method has previously been published as a screening method, but the scope has now been extended to quantification and confirmation. Nineteen compounds from five different classes of antibiotics, i.e. tetracyclines, sulfonamides, quinolones, (-lactams and macrolides, are included in the method. The samples are extracted by a single extraction using 70% methanol, diluted with water and injected in the LC-MS/MS. The run time is 7 min per injection. About 60 samples can be analysed in 24 h. By using this method the need for a separate screening step prior to confirmation is eliminated and consequently the total time from sampling to a confirmed result will be considerably reduced. Validation was performed according to Commission Decision 2002/657/EC. (c) 2008 Elsevier B.V All rights reserved.

引用

页码：87 / 91

页数：5

共 11 条

[1]

BOGAERTS R, 1980, FLEISCHWIRTSCHAFT, V60, P672

[2] A rapid confirmatory method for analyzing tetracycline antibiotics in bovine, swine, and poultry muscle tissues:: Matrix solid-phase dispersion with heated water as extractant followed by liquid chromatography-tandem mass spectrometry [J].

Bogialli, S ;

Curini, R ;

Di Corcia, A ;

Laganà, A ;

Rizzuti, G .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (05) :1564-1570

[3] Evaluation of the Premi® Test and comparison with the One-Plate Test for the detection of antimicrobials in kidney [J].

Cantwell, H ;

O'Keeffe, M .

FOOD ADDITIVES AND CONTAMINANTS, 2006, 23 (02) :120-125

[4] Confirmatory and quantitative analysis of β-lactam antibiotics in bovine kidney tissue by dispersive solid-phase extraction and liquid chromatography-tandem mass spectrometry [J].

Fagerquist, CK ;

Lightfield, AR ;

Lehotay, SJ .

ANALYTICAL CHEMISTRY, 2005, 77 (05) :1473-1482

[5] Rapid multi-residue screening of antibiotics in muscle and kidney by liquid chromatography-electrospray ionization-tandem mass spectrometry [J].

Granelli, K. ;

Branzell, C. .

ANALYTICA CHIMICA ACTA, 2007, 586 (1-2) :289-295

[6] Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry [J].

Kaufmann, Anton ;

Butcher, Patrick ;

Maden, Kathryn ;

Widmer, Mirjam .

JOURNAL OF CHROMATOGRAPHY A, 2008, 1194 (01) :66-79

[7] A microbiological six-plate method for the identification of certain antibiotic groups in incurred kidney and muscle samples [J].

Myllyniemi, AL ;

Nuotio, L ;

Lindfors, E ;

Rannikko, R ;

Niemi, A ;

Bäckman, C .

ANALYST, 2001, 126 (05) :641-646

[8]

Pang GF, 2005, J AOAC INT, V88, P1304

[9] Determination of (fluoro)quinolone antibiotic residues in pig kidney using liquid chromatography-tandem mass spectrometry I. Laboratory-validated method [J].

Toussaint, B ;

Chedin, M ;

Bordin, G ;

Rodriguez, AR .

JOURNAL OF CHROMATOGRAPHY A, 2005, 1088 (1-2) :32-39

[10] Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry [J].

Wang, J ;

Leung, D ;

Butterworth, F .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (06) :1857-1865

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