Identification of three allatostatins and their cDNA from the mosquito Aedes aegypti

被引：68

作者：

Veenstra, JA

Noriega, FG

Graf, R

Feyereisen, R

机构：

[1] UNIV ARIZONA, DEPT ENTOMOL, TUCSON, AZ 85721 USA

[2] UNIV ARIZONA, DEPT BIOCHEM, TUCSON, AZ 85721 USA

[3] UNIV ARIZONA, CTR INSECT SCI, TUCSON, AZ 85721 USA

[4] UNIV SPITAL ZURICH, DEPT CHIRURG, CH-8091 ZURICH, SWITZERLAND

来源：

PEPTIDES | 1997年 / 18卷 / 07期

关键词：

allatostatin; Aedes aegypti; convertase; trypsin; midgut; nervous system;

D O I：

10.1016/S0196-9781(97)00032-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three allatostatins have been isolated from the mosquito Aedes aegypti. These peptides have the following structures: Ser-Pro-Lys-Tyr-Asn-Phe-Gly-Leu-amide, Leu-Pro-His-Tyr-Asn-Phe-Gly-Leu-amide, and Arg-Val-Tyr-Asp-Phe-Gly-Leu-amide. A cDNA encoding these peptides was isolated from an abdominal ganglia cDNA library and sequenced. It was found to encode two additional allatostatins: Ala-Ser-Ala-Tyr-Arg-Tyr-His-Phe-Gly-Leu-amide and Leu-Pro-Asn-Arg-Tyr-Asn-Phe-Gly-Leu-amide. Northern analysis of whole mosquito mRNA revealed a single prepro-allatostatin message of around 3,000 bases. Identification of a partial prepro-allatostatin cDNA from a midgut cDNA library shows that the same gene is also expressed in the mosquito midgut. (C) 1997 Elsevier Science Inc.

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收藏

页码：937 / 942

页数：6

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