Synthesis and bioactivities of novel 4,5,6,7-tetrahydrothieno [2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production

被引：14

作者：

Fujita, M ^{[1
]}

Seki, T ^{[1
]}

Inada, H ^{[1
]}

Ikeda, N ^{[1
]}

机构：

[1] Nikken Chem Co Ltd, Omiya Res Lab, Saitama, Saitama 3300835, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00228-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 4,5,6,7-tetraliydrothieno[2,3-c]pyridine derivatives were synthesized and evaluated for their abilities to inhibit lipopolysaccharide (LPS)-stimulated production of TNF-alpha in rat whole blood. Several of these compounds exhibited potent inhibitory activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1607 / 1611

页数：5

共 18 条

[1] Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor [J].

Clements, JM ;

Cossins, JA ;

Wells, GMA ;

Corkill, DJ ;

Helfrich, K ;

Wood, LM ;

Pigott, R ;

Stabler, G ;

Ward, GA ;

Gearing, AJH ;

Miller, KM .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 74 (1-2) :85-94

[2]

DEZUBE BJ, 1992, J ACQ IMMUN DEF SYND, V5, P1099

[3] REPEATED THERAPY WITH MONOCLONAL-ANTIBODY TO TUMOR-NECROSIS-FACTOR-ALPHA (CA2) IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].

ELLIOTT, MJ ;

MAINI, RN ;

FELDMANN, M ;

LONGFOX, A ;

CHARLES, P ;

BIJL, H ;

WOODY, JN .

LANCET, 1994, 344 (8930) :1125-1127

[4]

ENGELBERTS I, 1991, LYMPHOKINE CYTOK RES, V10, P127

[5] Anti-TNFα therapy is useful in rheumatoid arthritis and Crohn's disease:: Analysis of the mechanism of action predicts utility in other diseases [J].

Feldman, M ;

Taylor, P ;

Paleolog, E ;

Brennan, FM ;

Maini, RN .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (08) :4126-4127

[6] Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis [J].

Feldmann, M ;

Elliott, MJ ;

Woody, JN ;

Maini, RN .

ADVANCES IN IMMUNOLOGY, VOL 64, 1997, 64 :283-350

[7] Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI) [J].

Fujita, M ;

Seki, T ;

Inada, H ;

Shimizu, K ;

Takahama, A ;

Sano, T .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (05) :771-774

[8] Cytokine expression and cell activation in inflammatory arthritis [J].

Ivashkiv, LB .

ADVANCES IN IMMUNOLOGY, VOL 63, 1996, 63 :337-376

[9]

Maini RN, 1998, ARTHRITIS RHEUM, V41, P1552, DOI 10.1002/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO

[10]

2-W

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