Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI)

被引：13

作者：

Fujita, M ^{[1
]}

Seki, T ^{[1
]}

Inada, H ^{[1
]}

Shimizu, K ^{[1
]}

Takahama, A ^{[1
]}

Sano, T ^{[1
]}

机构：

[1] Nikken Chem Co Ltd, Omiya Res Lab, Saitama 3300835, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(02)00005-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds 1 or 2 which possess dual-acting PAF antagonist/TxSI in a previous paper were modified and evaluated for the dual-acting activity. It was found that several compounds were potent dual-acting PAF antagonist/TxSI in and ex vivo. 6-(2-Chlorophenyl)-3-[4-[(E /Z)-6-ethoxvcarbonyl-1-(3-pyridyl)-1-hexenyl]phenylmethyl]-8,11-dimethyl-2,3.4,5-tetrahydro-8H-pyrido[4',3': 4.5]thieno[3.2-f][1,2,4]triazolo[4,3-a][1.4]diazepine (12) is excellent orally dual-acting PAF antagonist/TxSI. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：771 / 774

页数：4

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