Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs

被引：10

作者：

Fujita, M ^{[1
]}

Seki, T ^{[1
]}

Inada, H ^{[1
]}

Shimizu, K ^{[1
]}

Takahama, A ^{[1
]}

Sano, T ^{[1
]}

机构：

[1] Nikken Chem Co Ltd, Omiya Res Lab, Kitabukurocho, Saitama 3300835, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00731-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of compounds (22-36) which possess dual-acting PAF antagonist/TxSI have been generated by the approach of linking the known PAF antagonists and TxSIs, such as Ridogrel (1). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：341 / 344

页数：4

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