Assessment of hormonal activity of UV filters in tadpoles of frog Xenopus laevis at environmental concentrations

被引:17
作者
Kunz, PY
Galicia, HF
Fent, K
机构
[1] Univ Appl Sci, Inst Environm Technol, CH-4132 Muttenz, Switzerland
[2] Univ Zurich, Inst Plant Biol, Div Limnol, CH-8802 Kilchberg, Switzerland
[3] Springborn Smithers Labs Europe AG, CH-9326 Horn, Switzerland
[4] ETH, Swiss Fed Inst Technol, Dept Environm Sci, CH-8092 Zurich, Switzerland
关键词
UV filters; thyroid-mimicking activity; estrogenic activity; frog metamorphosis; Xenopus tadpoles;
D O I
10.1016/j.marenvres.2004.03.027
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Residues of UV filters used as ultraviolet absorbers in sunscreens, cosmetics and in light protection have been found in surface water and fish. Recently some of them were shown bearing estrogenic activity, however, very little is known about possible adverse effects to aquatic life. Here we investigate whether two UV filters, 4-methylbenzylidene camphor (4-MBC) and 3-benzylidene camphor (3-BC), interfere with the thyroid and sex hormone system during frog metamorphosis. Xenopus laevis tadpoles were exposed to 1, 5 and 50 mug/L of 4-MBC and 3-BC, respectively, for 35 days (NF stage 52-66). The rate of metamorphosis was not affected, and no obvious differences in body and tail length compared to controls were observed. Neither 4-MBC, nor 3-BC led to effects on the sex ratio or gross gonad morphology of X. laevis at stage 66. Our results indicate that these UV filters do not negatively affect the thyroid system and sex ratio of frogs at environmental concentrations. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:431 / 435
页数:5
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