The effect of pH on the LCST of poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid)

被引：101

作者：

Pei, Y ^{[1
]}

Chen, J ^{[1
]}

Yang, LM ^{[1
]}

Shi, LL ^{[1
]}

Tao, Q ^{[1
]}

Hui, BJ ^{[1
]}

Li, R ^{[1
]}

机构：

[1] Shanghai Univ, Sch Environm & Chem Engn, Dept Chem Engn & Technol, Shanghai 201800, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2004年 / 15卷 / 05期

关键词：

temperature sensitivity; pH sensitivity; LCST; PNIPAAm; P(NIPAAm-co-AAc);

D O I：

10.1163/156856204323046852

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(N-isopropylacrylamide) (PNIPAAm) and poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAAm-co-AAc)) hydrogels are synthesized by irradiating the aqueous solutions of NIPAAm and NlPAAm/AAc with Co-60 gamma-ray. The effects of pH on the swelling ratio and on the lower critical solution temperature (LCST) are studied by determining the dependence of swelling ratio on temperature in different pH butter solutions. Differential scanning calorimetry (DSC) is applied in determination of the LCST of the hydrogels. Fourier transform infrared (FT-IR) spectrometry is used in the comparison of hydrogels swelled in various pH conditions. As a result, PNIPAAm was found to be a pH-sensitive hydrogel and the LCST of the PNIPAAm and P(NIPAAm-co-AAc) hydrogels are influenced by pH.

引用

页码：585 / 594

页数：10

共 20 条

[1] New antibody purification procedure using a thermally responsive poly(N-isopropylacrylamide)-dextran derivative conjugate [J].