The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization

被引：70

作者：

Cancelas, Jose A.

Jansen, Michael

Williams, David A. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Res Fdn, Div Expt Hematol, Cincinnati, OH 45215 USA

[2] Univ Cincinnati, Coll Med, Hoxworth Blood Ctr, Cincinnati, OH USA

来源：

EXPERIMENTAL HEMATOLOGY | 2006年 / 34卷 / 08期

关键词：

D O I：

10.1016/j.exphem.2006.03.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Signaling downstream from the chemokine receptor CXCR4, the tyrosine kinase receptor c-kit and beta 1-integrins has been shown to be crucial in the regulation of migration, homing, and engraftment of hematopoietic stem cells and progenitors. Each of these receptors signal through Rac-type Rho guanosine triphosphatases (GTPases). Rac GTPases play a major role in the organization of the actin cytoskeleton and also in the control of gene expression and the activation of proliferation and survival pathways. Here we review the specific roles of the members of the Rac subfamily of the Rho GTPase family in regulating the intracellular signaling of hematopoietic cells responsible for regulation of homing, marrow retention, and peripheral mobilization. (c) 2006 International Society for Experimental Hematology.

引用

页码：976 / 985

页数：10

共 121 条

[21] Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses [J].