Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7

被引：35

作者：

Finch, A

Holland, P

Cooper, J

Saklatvala, J

Kracht, M

机构：

[1] KENNEDY INST,LONDON W6 8LH,ENGLAND

[2] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98109

[3] HANNOVER MED SCH,INST MOL PHARMACOL,D-30625 HANNOVER,GERMANY

来源：

FEBS LETTERS | 1997年 / 418卷 / 1-2期

关键词：

interleukin-1; mitogen-activated protein kinase; jun N-terminal kinase; stress-activated protein kinase; mitogen-activated protein kinase kinase 7; liver;

D O I：

10.1016/S0014-5793(97)01364-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) by interleukin-1 (IL-1) has been reported in many cells and in rabbit liver. Here we report selective activation of JNK/SAPK, without activation of p38 or p42 mitogen-activated protein kinases (MAPKs), by IL-1 in rabbit liver. We identified an IL-1 regulated JNK/SAPK activator present in rabbit liver using S Sepharose chromatography. It was purified and immunoprecipitated by two antisera to MAP kinase kinase 7 (MKK7). It was not recognised by an antibody to MKK4. We conclude that MKK7 is the activator of JNK/SAPK activated by IL-1 in liver and that JNK/SAPK is the only MAPK activated by IL-1 in liver. (C) 1997 Federation of European Biochemical Societies.

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页码：144 / 148

页数：5

相关论文

共 32 条

[1] Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart - p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion [J].

Bogoyevitch, MA ;

GillespieBrown, J ;

Ketterman, AJ ;

Fuller, SJ ;

BenLevy, R ;

Ashworth, A ;

Marshall, CJ ;

Sugden, PH .

CIRCULATION RESEARCH, 1996, 79 (02) :162-173

[2] PARALLEL SIGNAL-PROCESSING AMONG MAMMALIAN MAPKS [J].

CANO, E ;

MAHADEVAN, LC .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) :117-122

[3] Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells [J].

Cuenda, A ;

Alonso, G ;

Morrice, N ;

Jones, M ;

Meier, R ;

Cohen, P ;

Nebreda, AR .

EMBO JOURNAL, 1996, 15 (16) :4156-4164

[4] Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); Comparison of the specificities of SAPK3 and SAPK2 (RK/p38) [J].

Cuenda, A ;

Cohen, P ;

BueeScherrer, V ;

Goedert, M .

EMBO JOURNAL, 1997, 16 (02) :295-305

[5] JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN [J].

DERIJARD, B ;

HIBI, M ;

WU, IH ;

BARRETT, T ;

SU, B ;

DENG, TL ;

KARIN, M ;

DAVIS, RJ .

CELL, 1994, 76 (06) :1025-1037

[6] INDEPENDENT HUMAN MAP KINASE SIGNAL-TRANSDUCTION PATHWAYS DEFINED BY MEK AND MKK ISOFORMS [J].

DERIJARD, B ;

RAINGEAUD, J ;

BARRETT, T ;

WU, IH ;

HAN, JH ;

ULEVITCH, RJ ;

DAVIS, RJ .

SCIENCE, 1995, 267 (5198) :682-685

[7] Dual leucine zipper-bearing kinase (DLK) activates p46(SAPK) and p38(mapk) but not ERK2 [J].

Fan, G ;

Merritt, SE ;

Kortenjann, M ;

Shaw, PE ;

Holzman, LB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (40) :24788-24793

[8] INTERLEUKIN-1 ACTIVATES A NOVEL PROTEIN-KINASE CASCADE THAT RESULTS IN THE PHOSPHORYLATION OF HSP27 [J].

FRESHNEY, NW ;

RAWLINSON, L ;

GUESDON, F ;

JONES, E ;

COWLEY, S ;

HSUAN, J ;

SAKLATVALA, J .

CELL, 1994, 78 (06) :1039-1049

[9] Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); Comparison of its substrate specificity with that of other SAP kinases [J].

Goedert, M ;

Cuenda, A ;

Craxton, M ;

Jakes, R ;

Cohen, P .

EMBO JOURNAL, 1997, 16 (12) :3563-3571

[10]

GUESDON F, 1993, J BIOL CHEM, V268, P4236

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