Lipidated Ras and Rab peptides and proteins - Synthesis, structure, and function

被引:115
作者
Brunsveld, Luc
Kuhlmann, Juergen
Alexandrov, Kirill
Wittinghofer, Alfred
Goody, Roger S.
Waldmann, Herbert
机构
[1] Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany
[2] Univ Dortmund, Fachbereich Chem, D-44227 Dortmund, Germany
[3] Chem Genom Ctr, D-44227 Dortmund, Germany
关键词
bioorganic chemistry; GTPases; lipopeptides; lipoproteins; protein ligation;
D O I
10.1002/anie.200600855
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chemical biology can be defined as the study of biological phenomena from a chemical approach. Based on the analysis of relevant biological phenomena and their structural foundation, unsolved problems are identified and tackled through a combination of chemistry and biology. Thus, new synthetic methods and strategies are developed and employed for the construction of compounds that are used to investigate biological procedures. Solid-phase synthesis has emerged as the preferred method for the synthesis of lipidated peptides, which can be chemoselectively ligated to proteins of the Ras superfamily. The generated peptides and proteins have solved biological questions in the field of the Ras-superfamily GTPases that are not amendable to chemical or biological techniques alone. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:6622 / 6646
页数:25
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