Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in northern California

被引:112
作者
Mast, EE
Kuramoto, IK
Favorov, MO
Schoening, VR
Burkholder, BT
Shapiro, CN
Holland, PV
机构
[1] SACRAMENTO MED FDN,CTR BLOOD,SACRAMENTO,CA
[2] SACRAMENTO MED FDN,CTR BLOOD RES,SACRAMENTO,CA
关键词
D O I
10.1086/514037
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To evaluate antibody to hepatitis E virus (anti-HEV) seroreactivity, 5000 US blood donors were tested for anti-HEV by two EIAs: a mosaic protein assay (MPr-EIA) and a recombinant protein assay (RPr-EIA). Overall, 59 (1.2%) were seroreactive by MPr-EIA and 70 (1.4%) were seroreactive by RPr-EIA, The overall concordance between tests was 98.5% (4925/5000); the concordance among reactive sera by either test was only 27% (27/102). In a case-control study, seroreactive persons were more likely than seronegative persons to have traveled to countries in which HEV is endemic (odds ratio [OR] for MPr-EIA = 4.3, P < .001; OR for RPr-EIA = 2.5, P = .005), but 31% of MPr-EIA anti-HEV-reactive persons and 38% of RPr-EIA anti-HEV-reactive persons had no history of international travel, These findings suggest that travelers to regions in which HEV is endemic can acquire subclinical HEV infection. The significance of anti-HEV seroreactivity among persons without an international travel history needs to be determined.
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页码:34 / 40
页数:7
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